Sequential Mutations in the Interleukin-3 (IL3)/Granulocyte- Macrophage Colony-Stimulating Factor/IL5 Receptor b-Subunit Genes Are Necessary for the Complete Conversion to Growth Autonomy Mediated by a Truncated bC Subunit
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Cloning and Characterization of the Human Interleukin-3 (IL-3)/IL-5/ Granulocyte-Macrophage Colony-Stimulating Factor Receptor bc Gene: Regulation by Ets Family Members
High-affinity receptors for interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are composed of two distinct subunits, a ligand-specific a chain and a common b chain (bc). Whereas the mouse has two homologous b subunits (bc and bIL-3), in humans, only a single b chain is identified. We describe here the isolation and characterization of the gene encoding th...
متن کاملStructure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common b-chain bound to an antagonist
Heterodimeric cytokine receptors generally consist of a major cytokine-binding subunit and a signaling subunit. The latter can transduce signals by more than 1 cytokine, as exemplified by the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and IL-6 receptor systems. However, often the signaling subunits in isolation are unable to bind cytokines, a fact that has ...
متن کاملNeutrophils Activated by Granulocyte-Macrophage Colony-Stimulating Factor Express Receptors for Interleukin-3 Which Mediate Class I1 Expression
Freshly isolated peripheral blood neutrophils, unlike monocytes and eosinophils, do not bind interleukin-3 (IL-3) or respond t o IL-3. We show that neutrophils cultured for 24 hours in granulocyte-macrophage colony-stimulating factor (GM-CSF) express mRNA for the IL-3 receptor (R) a subunit, as shown by RNase protection assays, and lL-3Rn chain protein, as shown by flow cytometric analysis usin...
متن کاملThe Human Granulocyte - Macrophage Colony - Stimulating Factor ( GM - CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated
The granulocyte-macrophage colony-stimulating factor GM-CSF. The preformed complex required only the extracellular regions of GMRa and bc , as shown by the ability of (GM-CSF) receptor is expressed on normal and malignant hematopoietic cells as well as on cells from other organs soluble bc to associate with membrane-anchored GMRa or soluble GMRa. Kinetic experiments on eosinophils and in which ...
متن کاملDefective Expression of Granulocyte-Macrophage Colony-Stimulating Factor/Interleukin-3/Interleukin-5 Receptor Common b Chain in Children With Acute Myeloid Leukemia Associated With Respiratory Failure
Deficiency of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin-3 (IL-3)/IL-5 receptors common b chain (bc) is a cause of fatal respiratory failure. bc deficiency manifests as pulmonary alveolar proteinosis (PAP). PAP has heterogenous etiologies that may be genetic or aquired. Some cases of PAP have been reported to be associated with hematologic malignancies such as acu...
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